Comparison of nitrazepam and zopiclone in psychiatric patients.
نویسندگان
چکیده
This investigation compares the effects of single and double doses of nitrazepam (5 and 10 mg) and zopiclone (7.5 and 15 mg) and placebo for 1 night in 40 psychiatric patients. The results indicate that zopiclone is an active hypnotic compound, comparable in its effects to those of nitrazepam, the higher dosage being best adapted to the type of patients included in the study.
منابع مشابه
Comparison of short- and long-acting benzodiazepine-receptor agonists with different receptor selectivity on motor coordination and muscle relaxation following thiopental-induced anesthesia in mice.
In this study, we compared the effects of Type I benzodiazepine receptor-selective agonists (zolpidem, quazepam) and Type I/II non-selective agonists (zopiclone, triazolam, nitrazepam) with either an ultra-short action (zolpidem, zopiclone, triazolam) or long action (quazepam, nitrazepam) on motor coordination (rota-rod test) and muscle relaxation (traction test) following the recovery from thi...
متن کاملElectroencephalographic properties of zaleplon, a non-benzodiazepine sedative/hypnotic, in rats.
The encephalographic (EEG) properties of zaleplon were investigated in comparison with those of other sedative hypnotics in conscious rats with chronically implanted electrodes. The oral administration of zaleplon (0.25-1.0 mg/kg), triazolam (0.0625-0.25 mg/kg), zopiclone (1.0-4.0 mg/kg), brotizolam (0.0625-0.25 mg/kg), and nitrazepam (0.125-0.5 mg/kg) lengthened the total sleep in a dose-depen...
متن کاملبررسی میزان اثربخشی نیترازپام در مقایسه با دیازپام برای پیشگیری تشنج ناشی از تب
Background and Objective: Benzodiazepines are used for prophylaxis of febrile seizures. This study compares the effectiveness of intermittent Nitrazepam versus Diazepam therapy in preventing the recurrence of febrile seizures. Materials and Methods: This prospective randomized controlled trial was performed on neurologically normal children aged from 6 months to 3 years with a history of febril...
متن کاملA comparison of complex sleep behaviors with two short-acting Z-hypnosedative drugs in nonpsychotic patients
OBJECTIVE Complex sleep behaviors (CSBs) are classified as "parasomnias" in the International Classifcation of Sleep Disorders, Second Edition (ICSD-2). To realize the potential danger after taking two short-acting Z-hypnosedative drugs, we estimated the incidence of CSBs in nonpsychotic patients in Taiwan. METHODS Subjects (N = 1,220) using zolpidem or zopiclone were enrolled from the psychi...
متن کاملA 3-year survey quantifying the risk of dose escalation of benzodiazepines and congeners to identify risk factors to aid doctors to more rationale prescribing
OBJECTIVES This study investigated and quantified risk factors of dose escalation, as an indication of drug misuse and dependency of benzodiazepines and congeners, among presumably drug naïve patients in the Norwegian drug prescription database, observed over 3 years. DESIGN Observational study. SETTING Prescription database study. PARTICIPANTS We defined an excessive user as one redeemin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Pharmacology
دوره 27 Suppl 2 شماره
صفحات -
تاریخ انتشار 1982